Durian juice, which is extracted from durian fruit, has an odor that is quite offensive to some, being described as similar to smelling rotten onions, rotten fruit, road kill, moldy clothing, sewage or turpentine. Durian juice side effects are, therefore, experienced by individuals who dislike the odor.

These persons also tend to report a strong aftertaste of turpentine or alcohol. Sometimes, this taste is re-experienced throughout the day when people burp. Due to the strong odor, the fruit is banned from many public places, and could bring an offensive, lingering smell into the home.

When considering Durian juice side effects, one should be aware that uncooked durian seeds should not be processed into the juice, as they contain cyclopropene fatty acids, which are toxic.

Those restricting the intake of high glycemic foods should avoid drinking a lot of durian juice, which has a high glycemic content.